public class MainActivity extends AppCompatActivity {
    private MyHandler mHandler = new MyHandler(this);
    private TextView mTextView ;
    private static class MyHandler extends Handler {
        private WeakReference<Context> reference;
        public MyHandler(Context context) {
            reference = new WeakReference<>(context);
        }
        @Override
        public void handleMessage(Message msg) {
            MainActivity activity = (MainActivity) reference.get();
            if(activity != null){
                activity.mTextView.setText("");
            }
        }
    }

    @Override
    protected void onCreate(Bundle savedInstanceState) {
        super.onCreate(savedInstanceState);
        setContentView(R.layout.activity_main);
        mTextView = (TextView)findViewById(R.id.textview);
        loadData();
    }
   //loadData()方法是在子线程中，执行
    private void loadData() {
        //...request
        Message message = Message.obtain();
        mHandler.sendMessage(message);
    }

    @Override
    protected void onDestroy() {
        super.onDestroy();
        //如果你的Handler被delay（延时了）,可以做如下的处理
        mHandler.removeCallbacksAndMessages(null);
    }
}